Orion approaches this problem with the philosophy of "no fingerprinter running, no fingerprinting possible". This is because it is literally impossible to prevent fingerprinting from a sophisticated fingerprinter, if one is ever allowed to run.
So forget user agent/screen resolution/OS masking and other marketing talk used by browsers—this was maybe a thing 15 years ago, if ever. This does not protect you against sophisticated fingerprinters on the web.
The only efficient protection against fingerprinting is what Orion is doing - preventing any fingerprinter from running in the first place. Orion is the only browser on the market that comes with full first-party and third-party ad and tracking script blocking, built-in by default, making sure invasive fingerprinters never run on the page.